Cardiovascular effects of methylphenidate

Abstract

Methylphenidate is a stimulant medication that is often used in the treatment of Attention Deficit Hyperactivity Disorder. Because methylphenidate is a sympathomimetic agent, there have been concerns about potential adverse cardiovascular side effects. In this issue of The Journal, Hammerness et al report on a study which evaluated short and longer term cardiovascular safety of methylphenidate. They found that treatment with relatively high doses was associated with small, but significant increases in blood pressure and heart rate, especially during the first 6 months of treatment. There were no important EKG changes. Thus, in general, methylphenidate appears safe. However, it should be used with caution in patients with blood pressure elevation or other condition where an increase in heart rate or blood pressure would be disadvantageous. Methylphenidate is a stimulant medication that is often used in the treatment of Attention Deficit Hyperactivity Disorder. Because methylphenidate is a sympathomimetic agent, there have been concerns about potential adverse cardiovascular side effects. In this issue of The Journal, Hammerness et al report on a study which evaluated short and longer term cardiovascular safety of methylphenidate. They found that treatment with relatively high doses was associated with small, but significant increases in blood pressure and heart rate, especially during the first 6 months of treatment. There were no important EKG changes. Thus, in general, methylphenidate appears safe. However, it should be used with caution in patients with blood pressure elevation or other condition where an increase in heart rate or blood pressure would be disadvantageous.