CARDIOTROPHÝN 1 LEVELS IN NONDIPPER HYPERTENSIVE PATIENTS: PP.12.464

Abstract

Background: Cardiotrophin 1 (CT-1) is an interleukin cytokine with known hypertrophic and proctective actions upon cardiac myocytes. We know that CT-1 increases in hypertension. In nondipper hypertension there is a high risk for cardiovascular mortality as compared dipper hypertension. There is no study about CT-1 levels in nondipper hypertension. In our study we investigated CT-1 levels in nondipper hypertension. Material Method: Patients having ischemic heart disease, valvular heart diseases, heart failure, and having any other systemic or metabolic diseases were excluded. Patients haven't took any hypertension drugs when hypertension was diagnosed. Dipper and nondipper hypertensive patients were determined by 24 hour ambulatory blood pressure meassurement (Tracker NIBP2, Reynolds Medical Ltd. Hertford England). Twenty six nondipper patients (15 women, mean age: 60,0 ± 13,6 years) and 21 dipper (11 women, mean age: 54,3 ± 12,4 years) were included to the study. CT-1 were determined by ELISA method (Human Cardiotrophin 1 USCN Inc. Wuhan China). SPSS 10.0 packed programme T-Test was used for stastical analyses. Results: There were no differences in dipper and non-dipper patients regarding to age, sex, height and weight. We didn't find any difference CT1 levels in nondipper hypertension group and dipper hypertension group (9,92 ± 2,08; 9,75 ± 1,64 pg/ml, respectively). Conclusion: In this study we found that CT1 levels was similar in nondipper hypertension group and dipper hypertension group. Although cardiovascular diseases in nondipper hypertensive patients are higher than dipper hypertensive patients, CT-1 levels found similar in both group.