Abstract
Abstract Background: Renal and hepatotoxicity of diglycolic acid (DGA) has been described with in vitro cellular models as well as in vivo animal and human systems. The possibility of DGA being toxic
Highlights
Filler or thickener compounds present in dietary supplements or other foods often include carboxymethyl starches, such as carboxymethyl cellulose (CMC) [1]
We quantified the levels of reactive oxygen species (ROS) in H9c2 cultures exposed to diglycolic acid (DGA) or doxorubicin
The role of DGA in mediating cardiotoxicity has yet to be fully explored, but our study points to the possibility that it may compromise cell viability and affect the beat rate of cardiomyocytes
Summary
Filler or thickener compounds present in dietary supplements or other foods often include carboxymethyl starches, such as carboxymethyl cellulose (CMC) [1]. Our rat in vivo study, for example, revealed that after daily gavage dosing of different concentrations of DGA ranging up to 300 mg/kg BW, creatine kinase levels doubled or tripled in the animals that were treated with high doses of DGA, but no direct findings of gross or microscopic cardiac pathology [10]. These preliminary findings may suggest the possibility that the heart is vulnerable. A human case report identified the heart as a potential target organ of DGA, but an in-house in vivo rat study neither found gross nor microscopic pathological changes following repeated oral DGA exposure
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