Abstract
The present investigation has been undertaken to study the cardiotonic activity of parotoid gland secretion of common Indian Toad Bufo melanostictus on isolated perfused frog heart (Rana tigrina). Cardiotonic activity of parotoid gland secretion of B. melanostictus in normal as well as when induced with paraoxon (an organophosphate) was studied. For the evaluation of cardiotonic activity, Syme’s technique is being employed, digoxin and propranolol were used as standard drug and β-blocker respectively to characterize the effects on the receptors. The isolated perfused frog heart and hypodynamic frog heart showed dose dependent positive ionotrophic effects. The parotoid gland secretion exihibited cardiac stimulant activities. The propranolol was not able to block the effects of paraoxon induction on toad secretion. Thus, the present investigation reports that the parotoid gland secretion increased the force of contraction, heart beat and cardiac output in perfused frog’s heart, whereas, there was no change on hypodynamic heart, indicating that there may be existence of two components, one with β–receptor stimulating activity and other acting directly on the heart (independent of β1-adrenoreceptors).
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