Cardioprotective Action of Glycyrrhizin on Diabetic Rats with Myocardial Remodeling.

Fuxu Chen,Jie Song,Enas Abdulhay

doi:10.1155/2021/6343677

Abstract

Introduction Cardiovascular disorders are one of the prominent causes of risks of mortality which accounts for high rate of the deaths at a global level. The risk of deadly myocardial infraction grows because of diabetes which even causes the development of heart failure. Objective The objective of this study was to understand and study the effect of glycyrrhizin on diabetes suffering rats with myocardial remodeling. Materials and Methods Streptozotocin was used for induction of diabetes, and 8–12 weeks later, the assessment of inflammation, fibrosis, and cardiac damage was evaluated. Histopathological analysis and immunohistochemistry was performed to analyze the effect in various groups. Western blotting was performed to understand the proteins expressed in diabetes, and also, their expression was noted in treatment groups. Results There was a significant rise in TNF-α, dense fibrosis, and collagen deposits in the STZ diabetes group. The effects of hyperglycemia were significantly improved in the glycyrrhizin-treated group. DAPI, BrDu, and caspase staining was also performed to understand apoptosis in tissues where the diabetic groups reported significant apoptosis, while the effects were significantly lower in the treated group. Conclusion All the observations indicate that glycyrrhizin has cardioprotective action in diabetic rats with myocardial remodeling and is due to the inhibition of the NF-κB signaling pathway in the myocardial layer.

Highlights

Cardiovascular disorders are one of the prominent causes of risks of mortality which accounts for high rate of the deaths at a global level. e risk of deadly myocardial infraction grows because of diabetes which even causes the development of heart failure
E acute myocardial infarction heads to the ischemic necrosis of the myocardium which is considered to be harmful to the health of the mass population [6]. e timely widening of the coronary arteries in the patients suffering from the myocardial infraction diminishes the region of myocardial infraction, and there is an outstanding reduction in the mortality rate [7]. ere is multiple known as well as unknown components that might affect the myocardial impairments followed by interferences
Deposition of collagen in cardiac fibrosis in the Streptozotocin TGF-β (STZ) diabetic rats, control group, and glycyrrhizin-treated groups was analyzed histopathologically, where it was found that collagen deposits were significantly higher in the diabetic groups as compared to the treated and control groups (Figure 6)

Summary

Introduction

Cardiovascular disorders are one of the prominent causes of risks of mortality which accounts for high rate of the deaths at a global level. e risk of deadly myocardial infraction grows because of diabetes which even causes the development of heart failure. Cardiovascular disorders are one of the prominent causes of risks of mortality which accounts for high rate of the deaths at a global level. E objective of this study was to understand and study the effect of glycyrrhizin on diabetes suffering rats with myocardial remodeling. DAPI, BrDu, and caspase staining was performed to understand apoptosis in tissues where the diabetic groups reported significant apoptosis, while the effects were significantly lower in the treated group. Acute myocardial infraction (AMI) is considered among those with the high mortality rate, and the infarct size is a chief determinant of prognosis in the patients. E circulation of the high level of glucose might guide to the modified cardiomyocyte signaling which results in oxidative stress, fibrosis, and to the death of the myocyte cell [3]. E acute myocardial infarction heads to the ischemic necrosis of the myocardium which is considered to be harmful to the health of the mass population [6]. e timely widening of the coronary arteries in the patients suffering from the myocardial infraction diminishes the region of myocardial infraction, and there is an outstanding reduction in the mortality rate [7]. ere is multiple known as well as unknown components that might affect the myocardial impairments followed by interferences.

Methods

Findings

Discussion

Conclusion