Cardiomyopathies: Classification, Clinical Characterization, and Functional Phenotypes

Danuta Szczesna-Cordary,Sachio Morimoto,Aldrin V Gomes,Jeffrey R Moore

doi:10.1155/2012/870942

Abstract

Cardiomyopathies: Classification, Clinical Characterization, and Functional Phenotypes

Highlights

Editorial Cardiomyopathies: Classification, Clinical Characterization, and Functional Phenotypes
While DCM and RCM are associated with a progressive disease phenotype, heart failure, and sudden death, HCM is the leading cause of sudden cardiac death (SCD) in young athletes and is one of the most common forms of heart diseases affecting children
The L29Q mutation caused a small decrease in myofilament Ca2+ sensitivity, which was linked to an increase in the tropomyosin-troponin regulatory unit “off ” rate

Summary

Introduction

Editorial Cardiomyopathies: Classification, Clinical Characterization, and Functional Phenotypes While DCM and RCM are associated with a progressive disease phenotype, heart failure, and sudden death, HCM is the leading cause of sudden cardiac death (SCD) in young athletes and is one of the most common forms of heart diseases affecting children. Hundreds of mutations in genes encoding all major sarcomeric proteins have been identified to cause HCM, DCM, or RCM.

Results

Conclusion