Abstract
Domperidone, Parkinson disease and sudden cardiac death: Mice and men show the way
Highlights
I Universidade Federal de Sao Paulo (EPM/UNIFESP), Escola Paulista de Medicina, Disciplina de Neurociencia, Sao Paulo/SP, Brazil
The pathophysiology of Sudden cardiac death (SCD) is heterogeneous, but SCD is caused by electric instability and lethal ventricular arrhythmias followed by hemodynamic collapse [1]
In the same studies, ‘‘sudden’’ death occurred in many patients with acute catastrophic neurological diseases or chronic neurological disorders with acute decompensation [9]. Following this line of reasoning and because Parkinson disease (PD) has been neglected in this field of research, it is appropriate to consider the possible occurrence of SCD among individuals with PD and highlight these possibilities in the current scientific scenario
Summary
I Universidade Federal de Sao Paulo (EPM/UNIFESP), Escola Paulista de Medicina, Disciplina de Neurociencia, Sao Paulo/SP, Brazil. Some studies suggest that mortality over time among PD individuals is inconsistent [15], observational, meta-analysis and systematic review studies conducted over the last decades have demonstrated that PD is a condition that, in certain situations, is accompanied by high rates of premature death compared with the general population [10,16,17,18,19,20]. Neurologists have attempted to identify the risk factors for sudden death in individuals with PD, but the knowledge in this area is still limited.
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