Abstract
Although bipolar disorder is characterized by adverse effects on mood and social functioning, it is also associated with poor physical health. Some of the most prevalent comorbidities affecting individuals with bipolar disorder include those of a cardiometabolic nature, such as obesity, insulin resistance, and cardiovascular disease.1,2 In addition to detracting from physical wellbeing, there is growing awareness that comorbid medical conditions in people with bipolar disorder contribute to poorer psychiatric treatment outcomes and are associated with more severe mood symptoms.3–5 These comorbid conditions may arise from overlapping biological pathways that promote the development of both mood dysregulation and altered metabolism. In this article, the scope of cardiometabolic health concerns in bipolar disorder will be reviewed, including the prevalence of modifiable risk factors, pathophysiological correlates linking metabolic dysregulation and mood, and potential genetic vulnerabilities that contribute to the development of cardiometabolic illness and mood disorders. Novel treatment approaches that target improvement of metabolic health as a means of improving mood, cognition, and other psychiatric symptoms will also be discussed.
Accepted Version (
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Published Version
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