Abstract
Poor cell engraftment rate is one of the primary factors limiting the effectiveness of cell transfer therapy for cardiac repair. Recent studies have shown that the combination of cell-based therapy and tissue engineering technology can improve stem cell engraftment and promote the therapeutic effects of the treatment for myocardial infarction. This mini-review summarizes the recent progress in cardiac tissue engineering of cardiovascular cells from differentiated human pluripotent stem cells (PSCs), highlights their therapeutic applications for the treatment of myocardial infarction, and discusses the present challenges of cardiac tissue engineering and possible future directions from a clinical perspective.
Highlights
Ischemic heart disease (IHD) is a leading cause of death worldwide and a major contributor to the global health and economic burden
A study using tumor-initiating stem-like cells showed that a matrix made of fibrin gel promoted H3K9 demethylation and Sox2 expression [27], both of which are known to be involved in iPSC reprogramming [28,29]
Recent advances in tissue engineering allow for the designing of cellular structures or the incorporation of molecules to control the mechanical force and the release of certain factors that affect the differentiation of pluripotent stem cells (PSCs)
Summary
Ischemic heart disease (IHD) is a leading cause of death worldwide and a major contributor to the global health and economic burden. Engineered cardiac tissue from the derivatives of human induced pluripotent stem cells (hiPSC) can develop functional cardiac tissue for cell transfer therapy, and can be used for modeling heart disease and screening drugs in vitro [10,11]. This mini-review will summarize the recent progress in tissue engineering of cardiovascular cells from differentiated hPSCs and their therapeutic applications for the treatment of MI. Biomaterial scaffolds, which mimic the natural extracellular matrix (ECM) environment, have been extensively investigated for the engineering of cardiac tissues for PSC reprogramming, differentiation, and treatment of MI
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