Abstract
Background and aim Obesity confers an enormous burden of cardiovascular morbidity and mortality worldwide. Lipotoxicity has been implicated as a potential common pathway in myocyte dysfunction and ultimately apoptosis. Fat deposition in the peritoneum, the liver and around vascular structures has been linked to metabolic syndrome and subsequent cardiomyopathy. Therefore this study sought to determine the relationship between excess body fat and intracardiac lipids as assessed by 3T proton spectroscopy in women. Methods
Highlights
Background and aimObesity confers an enormous burden of cardiovascular morbidity and mortality worldwide
Lipotoxicity has been implicated as a potential common pathway in myocyte dysfunction and apoptosis
Fat deposition in the peritoneum, the liver and around vascular structures has been linked to metabolic syndrome and subsequent cardiomyopathy
Summary
Cardiac steatosis is associated with excess body weight in otherwise healthy adults Rajarshi Banerjee*, Belen Rial, Joseph J Suttie, Pete Cox, Adam J Lewandowski, Andrew Johnson, Oliver Rider, Cameron Holloway, Jane Francis, Matthew D Robson, Jurgen Schneider, Kieran Clarke, Paul Leeson, Stefan Neubauer. This study sought to determine the relationship between excess body fat and intracardiac lipids as assessed by 3T proton spectroscopy in women. Intracardiac lipid content correlated strongly with waist circumference, BMI and sagittal abdominal diameter (Fig 1). There was a significant correlation between ICL and visceral adiposity (Fig 2) and total body fat (r = 0.74, p < 0.001). In this healthy population, there was no significant relationship between left ventricular ejection fraction and intracardiac lipids, but there was a
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