Abstract

Cardiac single photon emission computed tomography (SPECT)/computed tomography (CT) imaging is facilitated by the dissemination of SPECT/CT hybrid systems and dedicated image fusion software. The combined approach of SPECT and CT has various advantages when compared with stand-alone imaging. CT attenuation correction can correct attenuation artifacts in myocardial SPECT and improves diagnostic accuracy for patients with coronary artery disease (CAD). Cardiac SPECT/CT hybrid imaging allows detection of coronary artery stenoses and abnormalities in myocardial perfusion and fatty-acid metabolism in patients with cardiac disease. It has been reported that this modality improves diagnostic accuracy in the detection of CAD compared to the individual imaging techniques. Furthermore, this approach facilitates the detection of hemodynamically significant coronary artery stenoses and the management of revascularization procedures. These abilities of cardiac hybrid SPECT/CT imaging will be further refined validating a range of clinical applications in large-scale clinical trials.

Highlights

  • Myocardial single photon emission computed tomography (SPECT) is a well-established diagnostic modality for the evaluation of myocardial ischemia or metabolic disorder in various cardiac diseases as well as for the risk stratification of coronary artery disease (CAD)

  • The present review provides an overview of the most important clinical aspects of cardiac SPECT/CT imaging, on computed tomography attenuation correction (CTAC) and cardiac SPECT/CT hybrid imaging

  • The additional information provided by cardiac SPECT/CT hybrid imaging can be used in combination with myocardial SPECT and coronary CT angiography (CCTA) to ascertain the interpretation of coronary artery territory in different individuals

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Summary

Introduction

Myocardial single photon emission computed tomography (SPECT) is a well-established diagnostic modality for the evaluation of myocardial ischemia or metabolic disorder in various cardiac diseases as well as for the risk stratification of coronary artery disease (CAD). Development in non-invasive modalities and imaging devices has driven the dissemination of coronary CT angiography (CCTA) and myocardial SPECT for patients with CAD. Cardiac SPECT/CT hybrid imaging can show the direct relationships between the distribution of coronary artery stenoses and myocardial ischemia, improving the diagnostic accuracy.

Results
Conclusion

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