Abstract
Background Diffuse myocardial fibrosis can be assessed by cardiac magnetic resonance (CMR) using the myocardial longitudinal relaxation time constant (T1). Mitral valve prolapse (MVP) is a common valvulopathy with known arrhythmic complications and in-vitro evidence of overexpression of pro-fibrotic TGF-beta. Papillary muscle fibrosis has been described in MVP, but the potential association of MVP with diffuse myocardial fibrosis is unknown. This association is important as it may increase our future understanding of ventricular arrhythmias in MVP.
Highlights
Diffuse myocardial fibrosis can be assessed by cardiac magnetic resonance (CMR) using the myocardial longitudinal relaxation time constant (T1)
Mitral valve prolapse (MVP) patients had greater Left ventricular (LV) end-diastolic volume and MRF compared to controls (136 ± 4.2 vs 84 ± 17 ml/m2, and 21 ± 24 vs 0%, both p < 0.05)
MVP is associated with reduced post-contrast T1 times despite preserved LV systolic function, suggestive of subclinical diffuse myocardial fibrosis
Summary
Diffuse myocardial fibrosis can be assessed by cardiac magnetic resonance (CMR) using the myocardial longitudinal relaxation time constant (T1). Mitral valve prolapse (MVP) is a common valvulopathy with known arrhythmic complications and in-vitro evidence of overexpression of pro-fibrotic TGF-beta. Papillary muscle fibrosis has been described in MVP, but the potential association of MVP with diffuse myocardial fibrosis is unknown. This association is important as it may increase our future understanding of ventricular arrhythmias in MVP
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