Cardiac Aldosterone Synthesis?

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Recognition that a variety of hormones affect the heart and blood vessels dates back well over a century, and about 25 years ago, it was firmly established that the heart is also an endocrine organ. This era began with de Bold’s1 discovery that the quantity of electron-dense “atrial specific granules” previously described by Jamieson and Palade2 varied with maneuvers that altered intravascular volume status. By 1982, it was recognized that these granules contained and released a potent peptide called atrial natriuretic peptide.