Abstract
Purpose To evaluate changes in high energy phosphate (HEP) metabolism in patients with hypertension and diastolic dysfunction but with normal LVEF > 55% assessed by echocardiography and tissue Doppler. Material and methods 20 patients (16 men and 4 women, mean age 57 ± 13 years) were studied with phosphorus magnetic resonance spectroscopy and echocardiography. MRS was performed at 1.5 T using an ECG-gated CSI sequence with nuclear Overhauser effect. According to echocardiographical findings 12 patients were found to have a diastolic dysfunction, whereas 8 patients were identified as normal, serving as control group in the following statistical analysis. All patients had normal systolic function (LVEF > 55%).Statistical analysis was made by using mean ± S.D. for description of the data, Spearman correlation and two-tailed Student's t-test for independent samples. Results No differences were found in weight, age, LVEF, endsystolic volume, end-diastolic volume, cardiac output and BNP levels between patients and control group. Myocardial mass at end-diastole correlated significantly with PCr/ATP ratio ( r = −0.66; p = 0.04) in patients and control group. Myocardial PCr/ATP ratio in patients was significantly decreased compared to controls (1.21 ± 0.22 vs. 1.54 ± 0.24; p = 0.006). Conclusions Cardiac 31P-MRS might offer a noninvasive means for detecting early states of heart failure in hypertensive patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have