Abstract
A 75-year-old man developed apparent acute left-sided orbital cellulitis over a three-day period. The vision in the left eye had gradually deteriorated to no light perception over four years. A superonasal epibulbar mass on clinical examination corresponded to the orbital computed tomographic finding of a soft-tissue density that extended through a large scleral defect. Biopsy of the mass was interpreted as consistent with malignant melanoma of the ciliary body with extrascleral extension. Because of gross proptosis due to extrascleral extension of the 'tumor' and persistent pain, a left orbital exenteration was performed. Pathologic examination revealed a partially necrotic tumor that filled the eye and extended through a large scleral defect into the orbit. Polygonal epithelioid and tumor spindle cells with marked nuclear pleomorphism were negative for immunohistologic markers for HMG-45 and S-100 protein and were surrounded by a basement membrane consistent with carcinoma of the nonpigmented ciliary bo...
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