Abstract
Highly polymerized grades of carboxymethylcellulose sodium serve effectively as disintegrating agents for tablets. The preferred disintegrants have a high degree of polymerization with a small number of carboxymethyl groups. Grades with a low degree of polymerization are poor disintegrating agents irrespective of their degree of substitution. The dissolution rates of sulfamethoxazole tablets correlated with the disintegration times.
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