Carboxymethyl β-cyclodextrin: Box-behnken model optimized synthesis, modification with cetyltrimethylammonium bromide and usage as sustained release system for curcumin

Abstract

Development of novel drug delivery systems is one of the major thrust areas in medicinal chemistry so as to localize, enhance and extend the action of the drug. To achieve maximum degree of Carboxymethylation of β-cyclodextrin in the present work, we first report the optimization of reaction conditions using box-behnken model of Response Surface Methodology. Thus synthesized Carboxymethylated β-cyclodextrin was modified using CTAB surfactant and again optimized for maximum binding efficiency for curcumin. The synthesis was confirmed using FT-IR, SEM, X-Ray Diffraction and Particle Size Analysis. Curcumin binding, release & solubility studies, anti-oxidant, Serum Protein protecting and anti-Cathepsin studies were executed for the modified support. The prepared support acted as a promising carrier for curcumin delivery with enhanced aqueous solubility.