Carbothermal treated ferrite nanoparticles with improved magnetic heating efficiency and T1-MRI performance

Abstract

Ferrite nanoparticle based T1-magnetic resonance imaging (T1-MRI) guided magnetic hyperthermia is a promising method for accurate tumor treatment. In previous studies, ultra-small sized ferrite nanoparticles were required to achieve excellent T1-MRI performance. However, an ultra-small size is usually accompanied by weak magnetization, resulting in a low magnetic heating efficiency, which is insufficient for magnetic hyperthermia. Therefore, ferrite nanoparticles with high magnetic heating efficiency and excellent T1-MRI performance capabilities are still highly desired. Here, oxygen vacancies are introduced in Mn0.6Zn0.4Al0.2Fe1.8O4 ferrite nanoparticles by applying carbothermal treatments. As oxygen vacancy concentrations increase, the intrinsic loss power increases up to 2.55 nH m2/kg, which is 33% higher than that of Fe3O4 nanoparticles used in magnetic hyperthermia. Specific absorption rate (SAR) calculations indicate that the predominant heat generation mechanism changes from hysteresis loss and relaxation loss to eddy current loss owing to conductivity enhancement by carbothermal treatments. The eddy current loss accounts for 70.6% of the total SAR, and plays a crucial role in increasing magnetic heating efficiency. In addition, Mn0.6Zn0.4Al0.2Fe1.8O4 ferrite nanoparticles with oxygen vacancies exhibit a significantly high r1 value of 9.69 mM−1 s−1 and a low r2/r1 ratio of 1.6 on a 3.0 T scanner. This is because oxygen vacancies naturally exhibit oxygen affinity in water molecules. The findings of this study could serve as a methodological reference of preparing ferrite nanoparticles for T1-MRI guided magnetic hyperthermia.