Abstract
A SYNTHETIC STRATEGY TO PREpare technetium(I) and rhenium (I) carboranes suitable for use as diagnostic and therapeutic reagents has been reported by assistant professor of chemistry John F. Valliant and coworkers at McMaster University in Hamilton, Ontario [ Inorg. Chem ., 41 , 628 (2002)]. Interest in the compounds is twofold: Carboranes, boranes, and other boron species are being used to prepare new compounds for boron neutron capture therapies that are being investigated as selective treatments for cancers and rheumatoid arthritis. In addition, the 99 m Tc isotope's nearly ideal nuclear properties for imaging have made it the most widely used radionuclide in diagnostic medicine. The McMaster researchers react [N(CH 2 CH 3 ) 4 ] 2 [M(CO) 3 Br 3 ] (M = 99 Tc, Re) with the dicarbollide anion nido - (C 2 B 9 H 12 )- to yield the metallacarboranes {N(CH 2 CH 3 )4 ][M(CO)3(C 2 B 9 H 11 )]. In an intermediate step, the dicarbollide anion is first deprotonated. Because there are no stable technetium isotopes ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
