Abstract

This study aimed to investigate whether carbonic anhydrase VI activity (CA VIACT ), pH, and buffering capacity (BC) in saliva and biofilm could predict the number of lesion occurrence and early childhood caries (ECC). A cross-sectional study was performed in a sample of 44 children aged 4 to 5years who were examined regarding their caries status (dmfs+active white spot lesions-WSL) and allocated into two groups: ECC and caries-free (CF). Saliva and biofilm were collected to determine pH, BC, and CA VIACT . Data were analyzed using the Student t test, and multiple linear regression and logistic regression analyses followed by the ROC curve. Children with ECC exhibited lower pH and BC in saliva and a higher CA VIACT in both saliva and biofilm. Only saliva pH could predict the dmfs+active WSL. In biofilm, if CA VIACT is increased by one pixel/µg, 0.85±0.28 increase is expected in the number of active WSL. Salivary pH and CA VIACT in saliva and biofilm had the power to predict ECC occurrence. Changes in saliva pH and CA VIACT in biofilm predicted the number of lesion occurrence. Furthermore, CA VIACT in both saliva and biofilm can predict propensity for ECC.

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