Carbonic anhydrase isoenzyme B in the erythrocytes of uremic subjects

Abstract

A specific and quantitative immunological method for determination of human erythrocyte carbonic anhydrase isoenzyme B has been used to determine the contents of enzyme in the erythrocytes from healthy persons and subjects with uremia. The investigations have shown a significant increase of carbonic anhydrase type B in the erythrocytes of patients with renal failure. Correlation was found between human erythrocyte carbonic anhydrase type B and Pt-creatinine-clearance but not between it and plasma standardbicarbonate.