Abstract
Carbon paste- and polyvinyl chloride membrane electrodes are simple, precise, rapid and selective sensors for the determination of antidiabetic drugs for type 2 diabetic patients. These electrodes were successfully used for the potentiometric determination of rosiglitazone, pioglitazone, glimepiride and glyburide in their standard forms and also as pharmaceutical preparations. The preparation of these ion-selective electrodes for the potentiometric determination of the drug is based on the construction of a 10% standard drug-ion pair with reineckate or tungstophosphate imbedded as an electro-active material in the carbon paste or in the polyvinyl chloride membrane. The prepared ion-selective electrodes showed a Nernstian response with a limit of detection amounting to 10(-6) M in a pH range of 3 to 5. A good selectivity coefficient and long term stability could be achieved. The developed potentiometric method based on the CPE and PVC sensors is economic and less time consuming compared to the conventionally used high performance liquid chromatography, HPLC, methods.
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