Abstract
Biocompatible nanomaterials have attracted enormous interest for biomedical applications. Carbonaceous materials, including carbon nanotubes (CNTs), have been widely explored in wound healing and other applications because of their superior physicochemical and potential biomedical properties to the nanoscale level. CNTs-based hydrogels are widely used for wound-healing and antibacterial applications. CNTs-based materials exhibited improved antimicrobial, antibacterial, adhesive, antioxidants, and mechanical properties, which are beneficial for the wound-healing process. This review concisely discussed the preparation of CNTs-based hydrogels and their antibacterial and wound-healing applications. The conductive potential of CNTs and their derivatives is discussed. It has been observed that the conductivity of CNTs is profoundly affected by their structure, temperature, and functionalization. CNTs properties can be easily modified by surface functionalization. CNTs-based composite hydrogels demonstrated superior antibacterial potential to corresponding pure polymer hydrogels. The accelerated wound healing was observed with CNTs-based hydrogels.
Highlights
The annual wound care costs are estimated to be several billion dollars, which constitute approximately 2–3% total expenditure on health [1]
This review describes the preparation of carbon nanotubes (CNTs)-based hydrogels and their potential applications for skin dressing and antibacterial
multi-walled carbon nanotubes (MWCNT) are comprised of multilayer graphene sheets rolled with a diameter of 2–50 nm; the outer layer dimeters can reach up to 100 nm, and the inner layer diameter is below 1 nm
Summary
The annual wound care costs are estimated to be several billion dollars, which constitute approximately 2–3% total expenditure on health [1]. Several studies have investigated the development of inorganic conductive materials in combination with non-conductive polymers to support the proliferation and electro-stimuli responsive cell activities [2] These materials are mainly carbon-based (CNTs and graphene oxide) and metals, which acquired the potential properties for biomedical applications. CNTs-based nanomaterials have received significant interest from the scientific community and have been widely studied for broad research topics due to their excellent electrical, electronic, and physicochemical properties [15] for electrode materials, biomedical applications, biosensors, bio imaging, drug delivery, tissue engineering, wound healing, sorption materials, and catalysis [16]. Several studies have been conducted to explore the potential of CNTs-based materials in biomedical applications, drug delivery, tissue engineering, cancer therapies, implantable devices such as nanosensors, nanorobotics, antibacterial, and wound dressing [17,19,20].
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