Abstract
Carbon nanotubes loaded with peptides, proteins and drugs can translocate across the cellmembrane. This big advantage has attracted increasing attention to design a noveldelivery system using nanotubes. Polyoxometalate (POM) is a promising antitumordrug and it shows a very strong interaction with carbon nanotube surfaces. Inthis paper, a novel complex of POM-modified single-walled carbon nanotubes(SWNTs) and chitosan was fabricated through a layer-by-layer self-assemblyprocess. With the addition of SWNTs, the loading of POM in this thin film wasdoubled in the high ionic strength. The initial burst release of POMs in the(POM/chitosan)n thin film wassuppressed in the (POM-SWNT/chitosan)n thin film. Also the instability of POMs in a physiologically relevant pH environment wasovercome. The strong interaction between POMs and SWNTs was believed to bethe determinant factor in the higher loading and prolonged release of POMs in(POM-SWNT/chitosan)n thin films.
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