Abstract
In this study, the reduction of ranitidine (RNT) was studied on a carbon nanofiber modified glassy carbon sensor (CNF/GC). The method developed for the analysis is selective, reliable, and also environment- friendly as it involves the use of a solubilized system. Fabricated sensor, prior to analysis, was characterized by microscopic, spectroscopic, and electrochemical techniques to obtain considerable information about the morphology, composition, and sensitivity of the modified electrode towards the determination of RNT. A comprehensive study of various experimental conditions that affected the peak response was carried out. Under optimized experimental conditions, the modified sensor exhibited a linear response for the electrocatalytic reduction of RNT over a concentration range from 0.05 to 0.75 mg mL-1. Low limits of detection and quantification were obtained for the proposed sensor. The analytical utility of the developed method was justified by measuring the concentration of RNT in a pharmaceutical formulation.
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