Abstract
Objective To make a sensitive method for the determination of ranitidine in human plasma by HPLC-UC. Methods Plasma samples were extracted with C18 Solid phase columns. Chromatograph analysis was carried out with a C18 column and UV Detector which was set at 316 nm. Results Interior impurity in human plasma does not interfere with the determination of ranitidine and internal standard. Good linear relationship(r2=0.999) was obtained in the concentration range from 10.0 to 1000.02%. Conclusion This method is sensitive, selective and simple, is suitable for clinical pharmacokinetic and bioequivalent study of ranitidine. Key words: Ranitidine; HPLC-UV; Bioequivalent
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