Abstract
The present study examined the actions of the putative gaseous neurotransmitter carbon monoxide (CO) on secretion of corticotropin-releasing factor (CRF) from cultured primary rat hypothalamic cells. 6 h treatment of cells with 100% gaseous CO, or with the heme analog, hematin (100 μM) which produces CO as a by-product of its metabolism, increased basal secretion of CRF to 207 ± 8% and 200 ± 65% of control respectively. Zinc protoporphyrin IX (ZnPPIX) (0.3–100 μM), a selective inhibitor of CO formation, decreased CRF secretion in a dose-dependent manner. The changes in CRF secretion observed with hematin were attenuated during concurrent treatment with ZnPPIX. These studies suggest that basal secretion of CRF in the rat hypothalamus may be regulated by CO.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
