Abstract
Prostacyclin (PGI2) and its analogues have been reported to exert cardioprotective effects via the rhodopsin type PGI2 receptor, IP. Recently, a second signaling pathway of PGI2 via peroxisome proliferator-activated receptor (PPAR) δ was demonstrated. PPARδ has been shown to exert a pivotal role in maintaining constitutive myocardial fatty acid â oxidation (FAO).The objective of this study was to examine whether carbacyclin (cPGI2), a PGI2 analogue, up-regulates transcriptional expression of carnitine palmitoyl-transferase-1 (CPT-1), the rate-limiting enzyme in mitochondrial FAO, via PPAR δ in cardiomyocytes.
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