Abstract
Prostacyclin (PGI2) has been reported to exert cardio-protective effects via the rhodopsin-type PGI2 receptor, IP. Recently, a novel signaling pathway of PGI2 via peroxisome proliferator-activated receptor (PPAR) δ was demonstrated. PPARδ exerts a pivotal role in maintaining constitutive myocardial fatty acid β-oxidation (FAO). The objective of this study was to examine whether carbacyclin (cPGI2), a PGI2 analogue, up-regulates transcriptional expression of carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting enzyme in mitochondrial FAO, via PPARδ in cardiomyocytes.
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