Abstract
Capillary zone electrophoresis has been used for the determination of gatifloxacin from its pharmaceutical preparation (tablets), using fused silica capillary. Separation was performed after hydrodynamic injection; the separation was achieved by applying 21 Kv voltage. Phosphate buffer solution (pH 9.5) was used as separation electrolyte. Detection was at 280 nm using a UV- detector. Under these experimental conditions the analysis takes 8 min. A linearity range for gatifloxacin was between 20.0 μg mL−1 to 60.0 μg mL−1. The method was validated and was found to be specific, precise, accurate, reproducible and robust and can be applied for the routine analysis of gatifloxacin from formulation and bulk drug.
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