Abstract
Capillary electrochromatography (CEC) shows promising results in the separation of basic drugs. Traditional reversed-phase systems, with or without amine additives to the mobile phase to improve peak shapes, are the most commonly employed. Alternative useful stationary phases, such as strong cation exchangers and polymer-based continuous beds, are also discussed, as are methods to improve sensitivity by sample preconcentration. So far, studies performed on CEC have mainly been fundamental, but the technique is rapidly maturing and has many potential applications in the pharmaceutical field.
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