Canonical organization of opioid modulation of nociceptive circuits. Focus on "mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/Kv1.2 channels".

Abstract

Opioids are powerful analgesics that produce their effects at both spinal and supraspinal levels. These effects are largely mediated by actions at μ type opioid receptors (MORs). Using whole cell recordings from neurons in the basolateral amygdala (BLA) in acute brain slices, [Finnegan et al. (2006