Candidate gene methylation studies are at high risk of erroneous conclusions.

Abstract

EpigenomicsVol. 7, No. 1 CommentaryCandidate gene methylation studies are at high risk of erroneous conclusionsAndrey A Shabalin, Karolina A Aberg & Edwin JCG van den OordAndrey A ShabalinCenter for Biomarker Research & Personalized Medicine, Virginia Common-wealth University, PO Box 980533, Richmond, VA 23298, USASearch for more papers by this author, Karolina A AbergCenter for Biomarker Research & Personalized Medicine, Virginia Common-wealth University, PO Box 980533, Richmond, VA 23298, USASearch for more papers by this author & Edwin JCG van den OordAuthor for correspondence: E-mail Address: ejvandenoord@vcu.eduCenter for Biomarker Research & Personalized Medicine, Virginia Common-wealth University, PO Box 980533, Richmond, VA 23298, USASearch for more papers by this authorPublished Online:17 Feb 2015https://doi.org/10.2217/epi.14.70AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: candidate gene studyDNA methylationfalse discoveriesmethylome-wide association studyprincipal component analysisReferences1 Bell JT, Pai AA, Pickrell JK et al. 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The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.No writing assistance was utilized in the production of this manuscript.PDF download