Mendelian randomization: applications and limitations in epigenetic studies.

Abstract

EpigenomicsVol. 7, No. 8 CommentaryMendelian randomization: applications and limitations in epigenetic studiesCaroline L Relton & George Davey SmithCaroline L Relton*Author for correspondence: E-mail Address: caroline.relton@bristol.ac.uk MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UKSearch for more papers by this author & George Davey Smith MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UKSearch for more papers by this authorPublished Online:7 Dec 2015https://doi.org/10.2217/epi.15.88AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: causal inferenceDNA methylationepidemiologyepigeneticsmediationSNPPapers of special note have been highlighted as: • of interest; •• of considerable interestReferences1 Mathers JC, Strathdee G, Relton CL. 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The REGICOR study15 September 2016 | Human Molecular Genetics, Vol. 25, No. 20How to make DNA methylome wide association studies more powerfulXinyi Lin, Sheila Barton & Joanna D Holbrook7 April 2016 | Epigenomics, Vol. 8, No. 8 Vol. 7, No. 8 Follow us on social media for the latest updates Metrics Downloaded 297 times History Published online 7 December 2015 Published in print December 2015 Information© Future Medicine LtdKeywordscausal inferenceDNA methylationepidemiologyepigeneticsmediationSNPAcknowledgementsThe authors would like to thank members of the MRC Integrative Epidemiology Unit for their contribution in developing this area of research.Financial & competing interests disclosuresThe authors’ work related to the application of Mendelian randomization to epigenetics is supported by the Medical Research Council Integrative Epidemiology Unit at the University of Bristol (MC_UU_12013/1 and MC_UU_12013/2). This work was also supported by CRUK (grant number C18281/A19169). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download