Abstract
Cancer immunotherapy, as a new treatment modality, has been shown to be effective, especially in metastatic melanoma and lung cancer. Organ transplantation can be a life-saving procedure for patients with end-stage diseases of lung, heart, kidney and liver. While ironically, as improvements in organ transplantation have extended patients’ lives, new or recurrent postsurgical malignancies have become an increasing threat to their long-term survival, especially in patients after liver transplantation due to hepatocellular carcinoma. The feasibility of immunotherapy treatment for such patients is still to be investigated.
Highlights
Cancer immunotherapy, as a new treatment modality, has been shown to be effective, especially in metastatic melanoma and lung cancer
We will give a general review of the literature regarding cancer immunotherapy in addition to presenting reviewing 3 case reports of liver transplant patients treated with immunotherapy
Immunotherapy has become the focus of growing interest, especially after the impressive results of checkpoint blockade inhibitors in malignant melanoma and non– small cell lung cancer, which indicate the therapeutic potential of tumor-specific immune restoration
Summary
Immunotherapy has become the focus of growing interest, especially after the impressive results of checkpoint blockade inhibitors in malignant melanoma and non– small cell lung cancer, which indicate the therapeutic potential of tumor-specific immune restoration. Solid-OTRs were excluded from clinical trials with cancer immunotherapies because of their use of immunosuppressive agents[20,21]. Some patients have safely and effectively received checkpoint inhibitors therapy after kidney transplantation, and with the patients remaining on low-dose immunosupression during ipilimumab therapy and the closed monitor of kidney function, some of the patients experienced apparent benefits[22,23,24], the immunotherapy clinical trails in OTRs are still very lacking and need much more investigations. We summarize 3 cases of cancer immunotherapy in patients with new or recurrent tumors after liver transplantation
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