CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?

Abstract

Objective: This study aimed to assess the probability of cylomegalovirus, parvovirus B 19, and herpes simplex 1, 2 virusinfection to cause recurrent miscarriage.Study Design: Prospective study.Settings: Antenatal outpatient clinic of Mansoura University Hospital and Clinical pathology department, faculty ofMedicine, Mansoura University during the period from February 2005 to September 2006Methods: Patients included in the study were collected from those attending (he antenatal outpatient clinic of MansouraUniversity Hospitals and were grouped into 2 groups; those with prior recurrent miscarriage (3 or more), with nouterine malformation that may be a cause of recurrent miscarriage (excluded by hyslerosalpingograms) (11=50). Theother group included 12 women with normal pregnancy used as control. Blood samples were taken from each woman c<:sent to the clinical pathology department for detection Ig M by ELISA & PCR for the genomes,Results: Parvovirus IgM had the highest rate (84%) followed by HSVI. 2 IgM (50%) and CMV IgM (12%) ill therecurrent abortion group. In controls, only parvovirus B19 IgM was positive in 2 cases (16.7%). In PCR study for viralDNA, parvovirus B19 was positive in 24 cases (48%), HSV2 in 16 cases (32%) and CMV was positive in 6 cases(12%) in recurrent abortion group with statistically significant difference between both groups.Conclusion: We can conclude that viral infections might play a role in recurrent abortion especially parvovirus B19 andHSV2.