Investigation of Parvovirus B19 IgG and IgM antibodies with ELISA, distribution with regard to age groups and comparison with literature

Abstract

Objective: Human parvovirus is an un-enveloped, linear, single bundle DNA virus 18-26 nm in diameter which is common worldwide and causes an asymptomatic infection. The most common clinical manifestation is erythema infectiosum, it may also lead to aplastic crisis, arthropathy, neutropenia, thrombocytopenia and fetal infections. In this study, we aimed to determine parvovirus B19 sero-positivity rates, distribution according to age and contribute to epidemiologic data in our country. Patients and Methods: Results of pregnant women who were admitted to Kanuni Suleiman Hospital between January 2015 and January 2017, examined for parvovirus B19 infection and whose parvovirus B19 IgG/IgM antibodies were examined with ELISA method were recorded from patient files. Parvovirus B19 IgM and parvovirus B19 IgG test results were retrospectively analyzed. parvovirus B19 IgM and parvovirus B19 IgG were examined with ELISA method in accordance with recommendations of the manufacturer. Results: A total of 156 pregnant women whose parvovirus B19 IgG/IgM antibodies had been analyzed were included in the study. While parvovirus B19 IgG was positive in 64.7% of the patients, parvovirus B19 IgM alone positivity was not detected in any women. parvovirus B19 IgG and IgM were positive in 3 women. parvovirus B19 IgG positivity was greatest above 40 years and minimum in 18-25 age group. Conclusion: In conclusion, parvovirus B19 IgG positivity was found similar with that in other countries. We consider that studies conducted with different groups and in different regions would contribute to epidemiologic data.