Abstract
Objective: Quick diagnosis of COVID-19 has been an important factor to manage the ongoing pandemic at hospitals and other health facilities. We aimed to investigate the effects of PCR test on hemogram parameters in COVID-19 patients. Materials and Methods: We collected hemogram data of 120 nasopharyngeal and oropharyngeal combo swab PCR positive and 119 PCR negative patients admitted to our hospital’s COVID-19 clinics with COVID-19 symptoms between 1 April 2020 and 24 June2020. Results: Age, MPV and NLR were found to be higher; hemoglobin, neutrophil, lymphocytes, basophil, platelet, PCT, WBC levels were lower in PCR positive cases. The highest sensitivity, 75 % is found on WBC count with cut off 7.15. Conclusion:Lower leukocyte count than 7.15, lower neutrophil count than 4.91, greater NLR than 2.95, lower platelet than 221.5 may give an idea about the diagnosis of SARS-CoV-2 infection. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 391-397
Highlights
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)was identified in early 2020 and has caused more than 145 million confirmed cases and more than 3.000.000 deaths all over the world during the COVID-19 pandemic outbreak(1)
World Health Organisation (WHO) published a document which declares that single discriminatory target in RT-PCR tests is acceptedadequate in areas where COVID-19 virus is widely spread on 19th March 2020 at the beginning of the pandemic outbreak(13)
mean platelet volume (MPV) and neutrophil-lymphocyte ratio (NLR) were found to be significantly higher; hemoglobin, neutrophil, lymphocytes, basophil, platelet, PCT, WBC levels were lower in PCR positive cases than those of PCR negative cases
Summary
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)was identified in early 2020 and has caused more than 145 million confirmed cases and more than 3.000.000 deaths all over the world during the COVID-19 pandemic outbreak(1). “Confirmed case” is defined by WHO (World Health Organization)as “a person with laboratory confirmation of COVID-19 infection, irrespective of clinical signs and symptoms” (2). It seems like to affect plenty of people from all over the world for some more time according to modelling studies for the pandemic outbreak(3). WHO suggests real timereverse transcription polymerase chain reaction quantification RT-PCR (qRT-PCR) test to identify SARS-CoV-2 (4). RT-PCR is the gold standard test to determine SARS-CoV-2 infection presently (5). Expensive kits and biosafety environment necessities and false negative results are disadvantages of RT-PCR tests during pandemic outbreak. Time is very important to detect cases, contacts and to stop the transmission of the virus earlier
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