Abstract
Objective: Quick diagnosis of COVID-19 has been an important factor to manage the ongoing pandemic at hospitals and other health facilities.We aimed to investigate the effects of PCR test on hemogram parameters in COVID-19 patients. Materials and Methods: We collected hemogram data of 120 nasopharyngeal and oropharyngeal combo swab PCR positive and 119 PCR negative patients admitted to our hospital’s COVID-19 clinics with COVID-19 symptoms between 1 April 2020 and 24 June2020. Results: Age, MPV and NLR were found to be higher; hemoglobin, neutrophil, lymphocytes, basophil, platelet, PCT, WBC levels were lower in PCR positive cases.The highest sensitivity, 75 % is found on WBC count with cut off 7.15. Conclusion: Lower leukocyte count than 7.15, lower neutrophil count than 4.91, greater NLR than 2.95, lower platelet than 221.5 may give an idea about the diagnosis of SARS-CoV-2 infection. Bangladesh Journal of Medical Science Vol.20(5) 2021 p.118-124
Highlights
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)was identified in early 2020 and has caused more than 145 million confirmed cases and more than 3.000.000 deaths all over the world during the COVID-19 pandemic outbreak1
World Health Organisation (WHO) published a document which declares that single discriminatory target in RT-PCR tests is acceptedadequate in areas where COVID-19 virus is widely spread on 19th March 2020 at the beginning of the pandemic outbreak[13]
mean platelet volume (MPV) and neutrophil-lymphocyte ratio (NLR) were found to be significantly higher; hemoglobin, neutrophil, lymphocytes, basophil, platelet, PCT, WBC levels were lower in PCR positive cases than those of PCR negative cases
Summary
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)was identified in early 2020 and has caused more than 145 million confirmed cases and more than 3.000.000 deaths all over the world during the COVID-19 pandemic outbreak. “Confirmed case” is defined by WHO (World Health Organization)as “a person with laboratory confirmation of COVID-19 infection, irrespective of clinical signs and symptoms”[2]. It seems like to affect plenty of people from all over the world for some more time according to modelling studies for the pandemic outbreak[3]. WHO suggests real time reverse transcription polymerase chain reaction quantification RT-PCR (qRT-PCR) test to identify SARS-CoV-24. RT-PCR is the gold standard test to determine SARS-CoV-2 infection presently[5]. Expensive kits and biosafety environment necessities and false negative results are disadvantages of RT-PCR tests during pandemic outbreak. Time is very important to detect cases, contacts and to stop the transmission of the virus earlier
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