Can fetal genetic risk score for birth weight be accurately predicted using parental genotype?

Abstract

The cumulative effect of single nucleotide polymorphisms (SNPs) at genetic loci can be calculated to generate genetic risk scores (GRSs) for birth weight (BW). While fetal GRSs have the potential to individualize fetal growth assessment, it is difficult to obtain fetal DNA antenatally. However, parental DNA is readily accessible. Our objective was to determine whether fetal GRS for birthweight (GRS-BW) can be predicted from parental DNA, and secondarily whether predicted fetal GRS-BW is associated with actual BW.