Abstract
Sleep deprivation reduces an organisms ability to perform adult neurogenesis, the generation of new neurons in adulthood. Recently, researchers discovered that recovery in sleep deprivation causes the rate of adult neurogenesis to overshoot the normal rate, and then decline back to normal. This research focuses on brain-derived neurotrophic factor, and whether or not manipulating it and its related pathways could extend the overshoot effect to enhance adult neurogenesis in the long term. The conclusion that is expected from this research is that BDNF will be able to prolong the overshoot of adult neurogenesis that is induced by sleep deprivation. The work seeks to provide more control over the overshoot-and-decline effect of adult neurogenesis during recovery from sleep deprivation, opening new pathways to treatments involving the manipulation of adult neurogenesis.
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