Abstract
The Role of Dentate Gyrus Neurogenesis in Neuropsychiatric Disorders
Highlights
The hippocampus is tactically situated in the brain such that it has reciprocal connections to several other regions involved in emotional behaviors, such as stress responses and positive and negative reinforcement
In addition to the wellknown monoamine neurotransmitter hypothesis of depression, many parallel processes exist that play a role in depression, such as alterations in neurotrophic factors (e.g., brainderived neurotrophic factor (BDNF)) and the regulation of adult hippocampal neurogenesis
Three papers in this special issue discuss the neurogenesis hypothesis of depression, which postulates that the generation of new neurons in the adult dentate gyrus (DG) is involved in the etiology and treatment of depression
Summary
The hippocampus is tactically situated in the brain such that it has reciprocal connections to several other regions involved in emotional behaviors, such as stress responses and positive and negative reinforcement. The special issue reviews the most recent developments in dentate gyrus (DG) neurogenesis with regard to neuropsychiatric disorders. The review and research articles in this special issue indicate that DG neurogenesis can be conceptualized as a form of plasticity and that the alterations in DG neurogenesis can predict a spectrum of disorders associated with the hippocampus.
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