Abstract
BackgroundWhen considering the benefits of the 6-min walking test (6-MWT) in research fields and the need of treatment for moderate to severe obstructive sleep apnea (OSA) patients, research in this field is of great advantage and may have a significant role in therapeutic grounds.MethodsThis cross-sectional study was conducted on 47 patients with confirmed diagnosis of OSA in the National Research Institute of Tuberculosis and Lung Disease, Masih Daneshvari Hospital. The 6-MWT was performed the day after polysomnography. The correlation between the 6-MWT and paraclinical findings during polysomnography in OSA patients was investigated.ResultsIn cases with moderate to severe OSA, the male sex displayed correlation with high PCO2. Ages of patients examined displayed reversed correlation with the distance in the 6-MWT by observing the O2 saturation (Sat) at the end of the 6-MWT, displaying direct correlation with the duration of O2 Sat <90% during sleep. The BMI also showed reversed correlation with the distance in the 6-MWT. Similarly, the severity of the OSA had reversed correlation with the expected distance in the test. However, patients with higher duration of O2 Sat <90% during sleep had a higher reduction in O2 Sat during and after the 6-MWT. Patients with higher duration of O2 Sat <90% during sleep also completed less overall distance in the 6-MWT (P values <0.05 for all).ConclusionIt appears that the 6-MWT can be used in patients with OSA to predict severity of the desaturation in OSA beyond functional capacity. Also, it can help predict the severity of disease and assist in follow up of the OSA patients in terms of functional capacity and selection of the most appropriate treatment strategy to increase the physical ability of the patients.
Highlights
When considering the benefits of the 6-min walking test (6-MWT) in research fields and the need of treatment for moderate to severe obstructive sleep apnea (OSA) patients, research in this field is of great advantage and may have a significant role in therapeutic grounds
This study aimed to show the severity of OSA had reverse correlation with expected distance in moderate and severe OSA
The effect of nocturnal intermittent hypoxia on physical activity of individuals. Study design This cross-sectional study was conducted on 47 patients with confirmed diagnosis of OSA in the National Research Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital during 1 year period starting from August 2012 to June 2013
Summary
When considering the benefits of the 6-min walking test (6-MWT) in research fields and the need of treatment for moderate to severe obstructive sleep apnea (OSA) patients, research in this field is of great advantage and may have a significant role in therapeutic grounds. Obstructive Sleep Apnea (OSA) syndrome is a chronic disease affecting 9% of males and 4% of females It most commonly affects middle-aged individuals (Al Lawati et al, 2009). Recurrent episodes of the upper airway obstruction, which is often accompanied by increased respiratory effort results in hypoxia and transient nocturnal hypercapnia. This leads to increases in the autonomic sympathetic activity causing arterial vasoconstriction, which is regarded as an abnormal response to exercise (Kaleth et al, 2007). Muscle dysfunction is another explanation for limited physical activity in OSA patients.
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