Abstract
cAMP has numerous vascular protective effects, including inhibition of VSMC migration, although the underlying mechanisms are unknown. Data from our laboratory suggests that cAMP controls VSMC behaviour via actin cytoskeleton-remodelling and subsequent regulation of immediate response genes. The immediate early gene CCN1 encodes a matricellular protein implicated in migration of various cells. Here we tested the hypothesis that cAMP-induced actin-cytoskeleton remodelling modulates VSMC behaviour by inhibiting expression of CCN1.
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