Camel Milk Mitigates Hemato-Immunotoxic Impacts of Fenpropathrin Oral Intoxication in Male Rat

Abstract

Our study was done to investigate the hematological and immune related impacts of fenpropathrin (FNP) pyrethroid in male rats and to assess the mitigating effect of camel milk (CM). Sixty male rats were randomly separated into six equal groups (n=10). 1st control (C), 2nd corn oil (CO), 3rd camel milk (CM) groups were orally gavaged physiological saline, CO, and CM respectively at doses of 2ml/rat for 60 days. 4th (FNP treated); orally received FNP 7.06 mg/kg B.wt., 5th (CM+FNP pro/ co treated; received CM two weeks prior to and along with FNP), and 6th (FNP + CM co treated; received FNP followed by CM) day after day by the same previous doses, route, and duration. FNP intoxication significantly decreased RBC counts, HCT, MCHC, Hb content, phagocytosis %, phagocytic index, serum lysozyme activity, and IgM levels. FNP significantly increased leukogram, platelet count, TNFα and IL6. CM significantly attenuates the altered indices more significantly in the (CM+FNP pro/co treated) group than the (FNP+CM co treated) group. Spleen tissues of FNP treated rats revealed marked atrophy and hypocellularity of the lymphocytic follicles with apoptosis and necrosis of the lymphoied eliments. Furthermore; marked atrophy of thymic cortex with delination of cortex and medulla with multifocal lymphocytic deplation. It is concluded that CM significantly mitigates FNP induced alterations in hematological and immune related indices in male rats.