Abstract
IntroductionSepsis is a factor associated with respiratory muscle dysfunction in intensive care. ObjectiveTo determine change in maximal inspiratory mouth pressure (Pimax) and associated factors in septic and non-septic patients with mechanical ventilation. MethodsDescriptive study that analysed the clinical trial database “Efficacy of respiratory muscle training in weaning of mechanical ventilation in patients with mechanical ventilation for 48hours or more”. The difference in the median of the final Pimax between intervention groups according to sepsis and non-sepsis conditions, and the associated factors in each group were identified. ResultsIn both septic and non-septic patients, the difference in the mean change in Pimax within each group (intervention and control) was significant: sepsis group (P=.02 and P=.001) and non sepsis group (P=.0001 and P=.05). In septic patients the change in Pimax decreased by .07cmH2O (P=.01; 95% CI −.13; .01) over time in assisted modes before entering the protocol, and increased by 8.9cmH2O on receiving pulmonary rehabilitation. In non-septic patients, the change in Pimax decreased .11cmH2O over time in spontaneous modes after entering the protocol. ConclusionIn septic patients the change in Pimax decreased over time on mechanical ventilation in assisted modes and increased when receiving pulmonary rehabilitation; in non-septic patients, spontaneous modes decreased with mechanical ventilation over time.
Published Version
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