Abstract
Gastrointestinal tract cancers are among the most common malignancies that still lack reliable and highly specific biomarkers.Differential scanning calorimetry has been widely explored in the last decade for the detection of disease- and stage-specific changes in temperature-induced conformational transitions in blood plasma proteins. The goal of the present study was to explore the potential of calorimetry to follow colorectal cancer tumor development in rats treated with 1,2-dimethylhydrazine. The plasma calorimetric features are related to the sex, age and occurrence of proliferative lesions and tumor formations in the intestinal tract of treated animals. The process of tumor induction led to both stabilization of the plasma proteome and decreased similarity between the plasma calorimetric curves of healthy and diseased rats; therefore, these parameters might be regarded as indicators of malignant transformation of intestinal cells and progression of tumor formation.
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