Calmodulin binds conserved motifs in fibroblast growth factor homologous factors

Abstract

Voltage-gated sodium channels (Navs) are tightly regulated by multiple proteins that bind the intracellular C-terminal domain. These include calmodulin (CaM), a calcium-signaling protein that binds the Nav IQ motif, and fibroblast growth factor homologous factors (FGFs) that bind the Nav EF-hand-like domain (EFL) proximal to the plasma membrane. We discovered that two sequences in the N-terminal domain (NTD) of A-type FGFs (FGF11A, FGF12A, FGF13A, and FGF14A) bind both domains of calcium-saturated CaM (Mahling et al (2021) J.