Abstract
As an alpha particle emitter, astatine-211 (211At) has been suggested as a candidate for radioimmunotherapy; thus better understanding of optimum irradiation parameters, radioactivity yields and possible impurities during its production is of paramount importance. In this work, theoretical calculations of bismuth-209 (209Bi) target thickness were performed using the SRIM 2013 codes whereas radioactivity yields of 211At were calculated based on the TENDL 2015, TENDL 2017 and EXFOR nuclear cross-section data. The calculated yields were also compared with available experimental results published elsewhere. According to the calculated results, while 211At was readily produced at alpha particle energy of just over 20.7 MeV, the maximum expected end-of-bombardment (EOB) yield was as much as 136.84 MBq/μAh when 209Bi target was bombarded using 35-MeV alpha particles. However, at this alpha particle energy, safety concern should be raised due to possibly high level of Polonium-210 (210Po) radioactivity generated via 209Bi(α,3n)210At → 210Po nuclear reaction as an indirect impurity. Production of 211At was therefore recommended using alpha particles ranging from 25 to 28 MeV.
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