Abstract
The pivotal intracellular message for triggering catecholamine release from bovine adrenal chromaffin cells is an elevation in the concentration of cytosolic free Ca 2+ ([Ca 2+] i). Studies using video-imaging techniques have shown that a rise in [Ca 2+] i at the cell periphery, that is due to Ca 2+ entry, is the major activating signal for exocytosis. The cytoskeleton has been identified as a major regulatory site of exocytosis, with Ca 2+-induced disruption of the cortical actin network being required in order that previously restrained granules may have access to their exocytotic sites. The Ca 2+- and phospholipid-dependent annexin protein, calpactin, has been strongly implicated in a late stage of interaction between granules and the plasma membrane by both ultrastructural and biochemical studies.
Published Version
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